Manufacture and extraction of PLLA films with incorporated metal ions

Abstract For the in vitro examination of effects on cells and tissues metal ions derived from implants by wear corrosion, a system is needed to release controlled sustained manner. As small concentrations may have an impact biological systems, corresponding slow over defined period time necessary. Here, manufacturing method polymeric Poly(L-lactic acid) (PLLA) films with incorporated cobalt via dip coating reported. The establishment two analytical methods for detection quantification shown. High performance liquid chromatography enables concentration range 0.33 μg/mL up 33 sample solutions. Extraction solvent cast PLLA-cobalt-films shows feasibility method. Initial biocompatibility tests manufactured PLLA-cobaltfilms showed no adipose primary mesenchymal stem (adMSCs).